Dataset Information


Mus musculus

ABSTRACT: Gene regulation by CBP-p300 in the lens placode - E9.5

ORGANISM(S): Mus musculus  



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Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.

Wolf Louise L   Harrison Wilbur W   Huang Jie J   Xie Qing Q   Xiao Ningna N   Sun Jian J   Kong Lingkun L   Lachke Salil A SA   Kuracha Murali R MR   Govindarajan Venkatesh V   Brindle Paul K PK   Ashery-Padan Ruth R   Beebe David C DC   Overbeek Paul A PA   Cvekl Ales A  

Nucleic acids research 20130912 22

Lens induction is a classical embryologic model to study cell fate determination. It has been proposed earlier that specific changes in core histone modifications accompany the process of cell fate specification and determination. The lysine acetyltransferases CBP and p300 function as principal enzymes that modify core histones to facilitate specific gene expression. Herein, we performed conditional inactivation of both CBP and p300 in the ectodermal cells that give rise to the lens placode. Ina  ...[more]

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