Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Gene expression analysis of in vivo-grown tumors treated with compounds that either de-bulk the tumor or target cancer stem cells

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA213323 | ENA |

REPOSITORIES: ENA

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Publications


Radiotherapy is a curative treatment option in prostate cancer. Nevertheless, patients with high-risk prostate cancer are prone to relapse. Identification of the predictive biomarkers and molecular mechanisms of radioresistance bears promise to improve cancer therapies. In this study, we show that aldehyde dehydrogenase (ALDH) activity is indicative of radioresistant prostate progenitor cells with an enhanced DNA repair capacity and activation of epithelial-mesenchymal transition (EMT). Gene exp  ...[more]

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