Dataset Information


Mus musculus

ABSTRACT: Study of stem cells and progenitor cells in K14 Snail mice

ORGANISM(S): Mus musculus  



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Epidermal Snail expression drives skin cancer initiation and progression through enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potential.

De Craene B B   Denecker G G   Vermassen P P   Taminau J J   Mauch C C   Derore A A   Jonkers J J   Fuchs E E   Berx G G  

Cell death and differentiation 20131025 2

Expression of the EMT-inducing transcription factor Snail is enhanced in different human cancers. To investigate the in vivo role of Snail during progression of epithelial cancer, we used a mouse model with skin-specific overexpression of Snail. Snail transgenic mice spontaneously developed distinct histological subtypes of skin cancer, such as basal cell carcinoma, squamous cell carcinoma and sebaceous gland carcinoma. Development of sebaceous gland carcinomas strongly correlated with the direc  ...[more]

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