Dataset Information


Homo sapiens

ABSTRACT: Comparison of gene expression from thymocyte populations and equivalent OP9-DL1 cultured cells

ORGANISM(S): Homo sapiens  



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In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection.

Snauwaert S S   Verstichel G G   Bonte S S   Goetgeluk G G   Vanhee S S   Van Caeneghem Y Y   De Mulder K K   Heirman C C   Stauss H H   Heemskerk M H M MH   Taghon T T   Leclercq G G   Plum J J   Langerak A W AW   Thielemans K K   Kerre T T   Vandekerckhove B B  

Leukemia 20131004 4

Peripheral blood T cells transduced with a tumor-specific T-cell receptor (TCR) face problems of auto-reactivity and lack of efficacy caused by cross-pairing of exogenous and endogenous TCR chains, as well as short term in vivo survival due to activation and growth factor-induced differentiation. We here studied an alternative strategy for the efficient generation of naive CD8(+) T cells with a single TCR. TCR-transduced human postnatal thymus-derived and adult mobilized blood-derived hematopoie  ...[more]

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