Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Gene expression profiling in TPC1 cell line treated with the RTK inhibitor RPI-1

PROVIDER: PRJNA213907 | ENA |

REPOSITORIES: ENA

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Publications


Thyroid cancer incidence is rapidly increasing. Papillary Thyroid Carcinoma (PTC), the most frequent hystotype, usually displays good prognosis, but no effective therapeutic options are available for the fraction of progressive PTC patients. BRAF and RET/PTC are the most frequent driving genetic lesions identified in PTC. We developed two complementary in vitro models based on RET/PTC1 oncogene, starting from the hypothesis that miRNAs modulated by a driving PTC-oncogene are likely to have a rol  ...[more]

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