Dataset Information


Mus musculus

ABSTRACT: Gene expression profiling of liver-specific NCOR knockout mice

ORGANISM(S): Mus musculus  



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Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.

Sun Zheng Z   Feng Dan D   Fang Bin B   Mullican Shannon E SE   You Seo-Hee SH   Lim Hee-Woong HW   Everett Logan J LJ   Nabel Christopher S CS   Li Yun Y   Selvakumaran Vignesh V   Won Kyoung-Jae KJ   Lazar Mitchell A MA  

Molecular cell 20131121 6

Histone deacetylases (HDACs) are believed to regulate gene transcription by catalyzing deacetylation reactions. HDAC3 depletion in mouse liver upregulates lipogenic genes and results in severe hepatosteatosis. Here we show that pharmacologic HDAC inhibition in primary hepatocytes causes histone hyperacetylation but does not upregulate expression of HDAC3 target genes. Meanwhile, deacetylase-dead HDAC3 mutants can rescue hepatosteatosis and repress lipogenic genes expression in HDAC3-depleted mou  ...[more]

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