Genomics

Dataset Information

353

Mus musculus


ABSTRACT: Role of Tet1 in genomic imprinting erasure [RRBS-sperm]

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA214853 | ENA |

REPOSITORIES: ENA

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Publications

Role of Tet1 in erasure of genomic imprinting.

Yamaguchi Shinpei S   Shen Li L   Liu Yuting Y   Sendler Damian D   Zhang Yi Y  

Nature 20131201 7480


Genomic imprinting is an allele-specific gene expression system that is important for mammalian development and function. The molecular basis of genomic imprinting is allele-specific DNA methylation. Although it is well known that the de novo DNA methyltransferases Dnmt3a and Dnmt3b are responsible for the establishment of genomic imprinting, how the methylation mark is erased during primordial germ cell (PGC) reprogramming remains unclear. Tet1 is one of the ten-eleven translocation family prot  ...[more]

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