Dataset Information


Homo sapiens

ABSTRACT: Global Expression of Molecular Transporters in the Human Vaginal Tract

ORGANISM(S): Homo sapiens  



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Global expression of molecular transporters in the human vaginal tract: implications for HIV chemoprophylaxis.

Gunawardana Manjula M   Mullen Madeline M   Moss John A JA   Pyles Richard B RB   Nusbaum Rebecca J RJ   Patel Jignesh J   Vincent Kathleen L KL   Wang Charles C   Guo Chao C   Yuan Yate-Ching YC   Warden Charles D CD   Baum Marc M MM  

PloS one 20131015 10

BACKGROUND:Pre-exposure chemoprophylaxis (PrECP) using antiretroviral agents is a promising strategy for the prevention of sexual HIV transmission in women. Molecular transporters in the human vaginal tract (VT) may play a pivotal role in determining drug disposition and, consequently, pharmacodynamic outcomes in these efforts. Little is known, however, on the expression of these transporters in vaginal tissues, representing a critical knowledge gap. METHODOLOGY/PRINCIPAL FINDINGS:Our study anal  ...[more]

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