Dataset Information


Lumbricus terrestris strain:wild

ABSTRACT: Lumbricus terrestris strain:wild Transcriptome or Gene expression

ORGANISM(S): Lumbricus terrestris  



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A unique covalent bond in basement membrane is a primordial innovation for tissue evolution.

Fidler Aaron L AL   Vanacore Roberto M RM   Chetyrkin Sergei V SV   Pedchenko Vadim K VK   Bhave Gautam G   Yin Viravuth P VP   Stothers Cody L CL   Rose Kristie Lindsey KL   McDonald W Hayes WH   Clark Travis A TA   Borza Dorin-Bogdan DB   Steele Robert E RE   Ivy Michael T MT   Hudson Julie K JK   Hudson Billy G BG  

Proceedings of the National Academy of Sciences of the United States of America 20131216 1

Basement membrane, a specialized ECM that underlies polarized epithelium of eumetazoans, provides signaling cues that regulate cell behavior and function in tissue genesis and homeostasis. A collagen IV scaffold, a major component, is essential for tissues and dysfunctional in several diseases. Studies of bovine and Drosophila tissues reveal that the scaffold is stabilized by sulfilimine chemical bonds (S = N) that covalently cross-link methionine and hydroxylysine residues at the interface of a  ...[more]

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