Dataset Information


Mus musculus

ABSTRACT: Gene regulation in LPS-induced PTB in E15.5 C57BL/6 mice

ORGANISM(S): Mus musculus  



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N,N-dimethylacetamide regulates the proinflammatory response associated with endotoxin and prevents preterm birth.

Sundaram Sruthi S   Ashby Charles R CR   Pekson Ryan R   Sampat Vaishali V   Sitapara Ravikumar R   Mantell Lin L   Chen Chih-Hung CH   Yen Haoting H   Abhichandani Khushboo K   Munnangi Swapna S   Khadtare Nikhil N   Stephani Ralph A RA   Reznik Sandra E SE  

The American journal of pathology 20130612 2

The proinflammatory response leads to various types of pathologic pathways, including the development of preterm birth. Preterm birth occurs in 12% of deliveries in the United States and causes more than 70% of perinatal morbidity and mortality. The most common cause of spontaneous preterm birth is intrauterine infection in the mother. There is accumulating evidence indicating that the release of proinflammatory cytokines plays a critical role in the pathogenesis of inflammation-associated prema  ...[more]

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