Dataset Information


Homo sapiens

ABSTRACT: MicroRNA-150 Contributes to the Proficiency of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia by Regulating Expression of GAB1 and FOXP1 Genes

ORGANISM(S): Homo sapiens  



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miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1.

Mraz Marek M   Chen Liguang L   Rassenti Laura Z LZ   Ghia Emanuela M EM   Li Hongying H   Jepsen Kristen K   Smith Erin N EN   Messer Karen K   Frazer Kelly A KA   Kipps Thomas J TJ  

Blood 20140501 1

We examined the microRNAs (miRNAs) expressed in chronic lymphocytic leukemia (CLL) and identified miR-150 as the most abundant, but with leukemia cell expression levels that varied among patients. CLL cells that expressed ζ-chain-associated protein of 70 kDa (ZAP-70) or that used unmutated immunoglobulin heavy chain variable (IGHV) genes, each had a median expression level of miR-150 that was significantly lower than that of ZAP-70-negative CLL cells or those that used mutated IGHV genes. In sam  ...[more]

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