Genomics,Multiomics

Dataset Information

0

Homo sapiens


ABSTRACT: Variability in functional p53 reactivation by Prima-1Met/APR-246 in Ewing sarcoma

OTHER RELATED OMICS DATASETS IN: E-GEOD-49967

PROVIDER: PRJNA215713 | ENA |

REPOSITORIES: ENA

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Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma.

Aryee D N T DN   Niedan S S   Ban J J   Schwentner R R   Muehlbacher K K   Kauer M M   Kofler R R   Kovar H H  

British journal of cancer 20131015 10


<h4>Background</h4>Though p53 mutations are rare in ES, there is a strong indication that p53 mutant tumours form a particularly bad prognostic group. As such, novel treatment strategies are warranted that would specifically target and eradicate tumour cells containing mutant p53 in this subset of ES patients.<h4>Methods</h4>PRIMA-1(Met), also known as APR-246, is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell de  ...[more]

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