Dataset Information


Mus musculus

ABSTRACT: Genome-wide maps of histone modification in WT and MLL4-/- during brown preadipocyte differentiation

ORGANISM(S): Mus musculus  



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H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.

Lee Ji-Eun JE   Wang Chaochen C   Xu Shiliyang S   Cho Young-Wook YW   Wang Lifeng L   Feng Xuesong X   Baldridge Anne A   Sartorelli Vittorio V   Zhuang Lenan L   Peng Weiqun W   Ge Kai K  

eLife 20131224

Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for H3K4me1/2 on enhancers remain elusive. Furthermore, how these enzymes function on enhancers to regulate cell-type-specific gene expression is unclear. In this study, we identify MLL4 (KMT2D) as a major mammalian H3K4 mono- and di-methyltransferase with partial functional redundancy with MLL3 (KMT2C). Using  ...[more]

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