Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: PARK2 knockdown in 2 glioma cell lines

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA219200 | ENA |

REPOSITORIES: ENA

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Publications


Coordinate control of different classes of cyclins is fundamentally important for cell cycle regulation and tumor suppression, yet the underlying mechanisms are incompletely understood. Here we show that the PARK2 tumor suppressor mediates this coordination. The PARK2 E3 ubiquitin ligase coordinately controls the stability of both cyclin D and cyclin E. Analysis of approximately 5,000 tumor genomes shows that PARK2 is a very frequently deleted gene in human cancer and uncovers a striking pattern  ...[more]

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