Genomics

Dataset Information

118

Bacillus subtilis subsp. subtilis str. NCIB 3610


ABSTRACT: A Serine Sensor for Multicellularity in a Bacterium

ORGANISM(S): Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051  

PROVIDER: PRJNA219205 | ENA |

REPOSITORIES: ENA

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Publications


We report the discovery of a simple environmental sensing mechanism for biofilm formation in the bacterium Bacillus subtilis that operates without the involvement of a dedicated RNA or protein. Certain serine codons, the four TCN codons, in the gene for the biofilm repressor SinR caused a lowering of SinR levels under biofilm-inducing conditions. Synonymous substitutions of these TCN codons with AGC or AGT impaired biofilm formation and gene expression. Conversely, switching AGC or AGT to TCN co  ...[more]

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