Genomics

Dataset Information

0

Mus musculus


ABSTRACT: AMPK agonist AICAR improves cognition and motor coordination in young and aged mice

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA219209 | ENA |

REPOSITORIES: ENA

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Publications

AMPK agonist AICAR improves cognition and motor coordination in young and aged mice.

Kobilo Tali T   Guerrieri Davide D   Zhang Yongqing Y   Collica Sarah C SC   Becker Kevin G KG   van Praag Henriette H  

Learning & Memory 20140117 2


Normal aging can result in a decline of memory and muscle function. Exercise may prevent or delay these changes. However, aging-associated frailty can preclude physical activity. In young sedentary animals, pharmacological activation of AMP-activated protein kinase (AMPK), a transcriptional regulator important for muscle physiology, enhanced spatial memory function, and endurance. In the present study we investigated effects of AMPK agonist 5-aminoimidazole-4-carboxamide riboside (AICAR) on memo  ...[more]

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