Dataset Information


Homo sapiens

ABSTRACT: Gene expression profiling of human IL-10+ B-cells

ORGANISM(S): Homo sapiens  



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Human regulatory B cells combine phenotypic and genetic hallmarks with a distinct differentiation fate.

Lin Wenyu W   Cerny Daniela D   Chua Edmond E   Duan Kaibo K   Yi June Tai Jing JT   Shadan Nurhidaya Binte NB   Lum Josephine J   Maho-Vaillant Maud M   Zolezzi Francesca F   Wong Siew Cheng SC   Larbi Anis A   Fink Katja K   Musette Philippe P   Poidinger Michael M   Calbo Sébastien S  

Journal of immunology (Baltimore, Md. : 1950) 20140730 5

Regulatory B cells (B-reg) produce IL-10 and suppress inflammation in both mice and humans, but limited data on the phenotype and function of these cells have precluded detailed assessment of their contribution to host immunity. In this article, we report that human B-reg cannot be defined based on a phenotype composed of conventional B cell markers, and that IL-10 production can be elicited in both the CD27(+) memory population and naive B cell subset after only a brief stimulation in vitro. We  ...[more]

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