Dataset Information


Dictyostelium discoideum

ABSTRACT: Differential expression of Dictyostelium discoideum AX2 upon infection with wt L. pneumophila JR32 vs. uninfected 48h p.i. (timecourse experiment)



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Dictyostelium transcriptional host cell response upon infection with Legionella.

Farbrother Patrick P   Wagner Carina C   Na Jianbo J   Tunggal Budi B   Morio Takahiro T   Urushihara Hideko H   Tanaka Yoshimasa Y   Schleicher Michael M   Steinert Michael M   Eichinger Ludwig L  

Cellular microbiology 20060301 3

Differential gene expression of Dictyostelium discoideum after infection with Legionella pneumophila was investigated using DNA microarrays. Investigation of a 48 h time course of infection revealed several clusters of co-regulated genes, an enrichment of preferentially up- or downregulated genes in distinct functional categories and also showed that most of the transcriptional changes occurred 24 h after infection. A detailed analysis of the 24 h time point post infection was performed in compa  ...[more]

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