Dataset Information


Mus musculus

ABSTRACT: The gene expression analysis of the spinal cord and skeletal muscle of SBMA (Spinal Bulbar Muscular Atrophy) model mice with or without pioglitazone (PG) treatment

ORGANISM(S): Mus musculus  



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Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors.

Iida Madoka M   Katsuno Masahisa M   Nakatsuji Hideaki H   Adachi Hiroaki H   Kondo Naohide N   Miyazaki Yu Y   Tohnai Genki G   Ikenaka Kensuke K   Watanabe Hirohisa H   Yamamoto Masahiko M   Kishida Ken K   Sobue Gen G  

Human molecular genetics 20140828 2

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by the expansion of a CAG repeat in the androgen receptor (AR) gene. Mutant AR has been postulated to alter the expression of genes important for mitochondrial function and induce mitochondrial dysfunction. Here, we show that the expression levels of peroxisome proliferator-activated receptor-γ (PPARγ), a key regulator of mitochondrial biogenesis, were decreased in mouse and cellular models of SBMA. Treatment with piogli  ...[more]

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