Genomics

Dataset Information

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Rattus norvegicus


ABSTRACT: Reversible and irreversible differentiation of cardiac fibroblasts

ORGANISM(S): Rattus norvegicus  

PROVIDER: PRJNA225508 | ENA |

REPOSITORIES: ENA

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Publications

Reversible and irreversible differentiation of cardiac fibroblasts.

Driesen Ronald B RB   Nagaraju Chandan K CK   Abi-Char Joëlle J   Coenen Tamara T   Lijnen Paul J PJ   Fagard Robert H RH   Sipido Karin R KR   Petrov Victor V VV  

Cardiovascular research 20131223 3


AIMS: Differentiation of cardiac fibroblasts (Fbs) into myofibroblasts (MyoFbs) is responsible for connective tissue build-up in myocardial remodelling. We examined MyoFb differentiation and reversibility. METHODS AND RESULTS: Adult rat cardiac Fbs were cultured on a plastic substratum providing mechanical stress, with conditions to obtain different levels of Fb differentiation. Fb spontaneously differentiated to proliferating MyoFb (p-MyoFb) with stress fibre formation decorated with alpha-smoo  ...[more]

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