Genomics

Dataset Information

118

Homo sapiens


ABSTRACT: miR-134/487b/655 Cluster regulates TGF-β-induced epithelial-mesenchymal transition and drug resistance to Gefitinib by targeting MAGI2 in lung adenocarcinoma cells.

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA225520 | ENA |

REPOSITORIES: ENA

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Publications

MiR-134/487b/655 cluster regulates TGF-β-induced epithelial-mesenchymal transition and drug resistance to gefitinib by targeting MAGI2 in lung adenocarcinoma cells.

Kitamura Kazuhiro K   Seike Masahiro M   Okano Tetsuya T   Matsuda Kuniko K   Miyanaga Akihiko A   Mizutani Hideaki H   Noro Rintaro R   Minegishi Yuji Y   Kubota Kaoru K   Gemma Akihiko A  

Molecular cancer therapeutics 20131120 2


Epithelial-mesenchymal transition (EMT) has recently been recognized as a key element of cell invasion, migration, metastasis, and drug resistance in several types of cancer, including non-small cell lung cancer (NSCLC). Our aim was to clarify microRNA (miRNA)-related mechanisms underlying EMT followed by acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) in NSCLC. miRNA expression profiles were examined before and after transforming growth factor β1 (TG  ...[more]

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