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Mus musculus

ABSTRACT: Liver mRNA microarray study for mice treated with various diets

OTHER RELATED OMICS DATASETS IN: E-GEOD-51885

PROVIDER: PRJNA225676 | ENA |

REPOSITORIES: ENA

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E-GEOD-51885

Project description:Liver mRNA microarray study for mice treated with various diets

2015-07-27 | E-GEOD-51885 | ExpressionAtlas

Expression data from liver tissue of mice (Mus musculus)

Project description:The aim of this study was to assess whether chronic treatment with RPV can modulate the progression of chronic liver disease, especially of non-alcoholic fatty liver disease (NAFLD), through a nutritional model in wild-type mice Mice were daily treated with RPV (p.o.) and fed with normal or high fat diet during 3 months to induce fatty liver disease

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Dietary selenium levels affect selenoprotein expression and support the interferon-γ and IL-6 immune response pathways in mice [RNA-Seq]

Project description:Mice were fed Se-deficient or Se-adequate diets for 6 weeks. Liver and lung tissue were harvested and processed for RNA-Seq, ribosome profiling, and microarray analysis. From these studies, we identified changes in mRNA levels and translation of selenoprotein genes and genes regulated by interferon-gamma. Cytokine profiles of serum indicated that interferon-gamma and IL-6 levels were increased in the Se-adequate mice relative to Se-deficient mice. RNA-Seq analysis of liver tissue from mice fed Se-deficient or Se-adequate diets

2015-08-06 | E-GEOD-70158 | biostudies-arrayexpress

Dietary selenium levels affect selenoprotein expression and support the interferon-γ and IL-6 immune response pathways in mice [Ribosome Profiling]

Project description:Mice were fed Se-deficient or Se-adequate diets for 6 weeks. Liver and lung tissue were harvested and processed for RNA-Seq, ribosome profiling, and microarray analysis. From these studies, we identified changes in mRNA levels and translation of selenoprotein genes and genes regulated by interferon-gamma. Cytokine profiles of serum indicated that interferon-gamma and IL-6 levels were increased in the Se-adequate mice relative to Se-deficient mice. Ribosome profiling of liver tissue from mice fed Se-deficient or Se-adequate diets

2015-08-06 | E-GEOD-70159 | biostudies-arrayexpress

Dietary selenium levels affect selenoprotein expression and support the interferon-? and IL-6 immune response pathways in mice [microarray]

Project description:Mice were fed Se-deficient or Se-adequate diets for 6 weeks. Liver and lung tissue were harvested and processed for RNA-Seq, ribosome profiling, and microarray analysis. From these studies, we identified changes in mRNA levels and translation of selenoprotein genes and genes regulated by interferon-gamma. Cytokine profiles of serum indicated that interferon-gamma and IL-6 levels were increased in the Se-adequate mice relative to Se-deficient mice. Gene expression analysis of liver and lung tissue from mice fed Se-deficient or Se-adequate diets

2015-08-06 | E-GEOD-71716 | biostudies-arrayexpress

Male mus musculus transcriptomes from whole liver tissue

Project description:The ketogenic diet has been successful in promoting weight loss among patients that have struggled with weight gain. This is due to the cellular switch in metabolism that utilizes liver-derived ketone bodies for the primary energy source rather than glucose. Fatty acid transport protein 2 (FATP2) is highly expressed in liver, small intestine, and kidney where it functions in both the transport of exogenous long chain fatty acids (LCFA) and in the activation to CoA thioesters of very long chain fatty acids (VLCFA). We have completed a multi-omic study of FATP2-null (Fatp2-/-) mice maintained on a ketogenic diet (KD) or paired control diet (CD), with and without a 24-hour fast (KD-fasted and CD-fasted) to address the impact of deleting FATP2 under high-stress conditions. Control (wt/wt) and Fatp2-/- mice were maintained on their respective diets for 4-weeks. Afterwards, half the population was sacrificed while the remaining were fasted for 24-hours prior to sacrifice. We then performed paired-end RNA-sequencing on the whole liver tissue to investigate differential gene expression. The differentially expressed genes mapped to ontologies such as the metabolism of amino acids and derivatives, fatty acid metabolism, protein localization, and components of the immune system’s complement cascade, and were supported by the proteome and histological staining.

2020-06-10 | GSE152110 | GEO

Expression data from livers from mice receiving high-fat (HF) diets supplemented with different berries

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2015-06-01 | GSE66711 | GEO

Comparative global gene expression profiling of mice liver and spleen fed with nucleoprotein (NP) diets

Project description:A diet rich in nucleic acids and protamin protein, termed as nucleoprotein was used for the study. Mice were fed with NP diets for 4 weeks followed by removal of the liver and spleen. Total RNA extracted from livers and spleens was pooled in each group (low NP or LNP-control, and 1.2% NP-treatment, diets), prior to DNA microarray analysis (Agilent mouse whole genome 4 x 44K). Results revealed 1373 & 3386 up (>1.5 fold)- and down (<0.75 fold)-regulated genes in the liver, and 252 & 1838 up- and down-regulated genes in the spleen, respectively following 1.2%NP diet. Analysis of genes related to NP diets will be discussed.

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2015-08-06 | GSE71716 | GEO

Dietary selenium levels affect selenoprotein expression and support the interferon-γ and IL-6 immune response pathways in mice [RNA-Seq]

2015-08-06 | GSE70158 | GEO