Dataset Information


Mus musculus

ABSTRACT: ZHBTc4 ES cells stably expressing EGFP vs Nr5a2-EGFP or Oct4-EGFP vs Nr5a2-EGFP

ORGANISM(S): Mus musculus  



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The reprogramming factor nuclear receptor subfamily 5, group A, member 2 cannot replace octamer-binding transcription factor 4 function in the self-renewal of embryonic stem cells.

Choi Kyeng-Won KW   Oh Hye-Rim HR   Lee Jaeyoung J   Lim Bobae B   Han Yong-Mahn YM   Oh Junseo J   Kim Jungho J  

The FEBS journal 20131216 4

Although octamer-binding transcription factor 4 (Oct-4) is one of the most intensively studied factors in mammalian development, no cellular genes capable of replacing Oct-4 function in embryonic stem (ES) cells have been found. Recent data show that nuclear receptor subfamily 5, group A, member 2 (Nr5a2) is able to replace Oct-4 function in the reprogramming process; however, it is unclear whether Nr5a2 can replace Oct-4 function in ES cells. In this study, the ability of Nr5a2 to maintain self  ...[more]

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