Dataset Information


Homo sapiens

ABSTRACT: C10ORF10/DEPP, a transcriptional target of FOXO3 regulates ROS-sensitivity by destabilizing peroxisomes in human neuroblastoma

ORGANISM(S): Homo sapiens  



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C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma.

Salcher Stefan S   Hagenbuchner Judith J   Geiger Kathrin K   Seiter Maximilian A MA   Rainer Johannes J   Kofler Reinhard R   Hermann Martin M   Kiechl-Kohlendorfer Ursula U   Ausserlechner Michael J MJ   Obexer Petra P  

Molecular cancer 20140928

BACKGROUND:FOXO transcription factors control cellular levels of reactive oxygen species (ROS) which critically contribute to cell survival and cell death in neuroblastoma. In the present study we investigated the regulation of C10orf10/DEPP by the transcription factor FOXO3. As a physiological function of C10orf10/DEPP has not been described so far we analyzed its effects on cellular ROS detoxification and death sensitization in human neuroblastoma cells. METHODS:The effect of DEPP on cellular  ...[more]

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