Genomics

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ABSTRACT: Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers

PROVIDER: PRJNA230809 | ENA |

REPOSITORIES: ENA

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Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers.

Akat Kemal Marc KM   Moore-McGriff D'Vesharronne D   Morozov Pavel P   Brown Miguel M   Gogakos Tasos T   Correa Da Rosa Joel J   Mihailovic Aleksandra A   Sauer Markus M   Ji Ruiping R   Ramarathnam Aarthi A   Totary-Jain Hana H   Williams Zev Z   Tuschl Thomas T   Schulze P Christian PC  

Proceedings of the National Academy of Sciences of the United States of America 20140710 30


Heart failure (HF) is associated with high morbidity and mortality and its incidence is increasing worldwide. MicroRNAs (miRNAs) are potential markers and targets for diagnostic and therapeutic applications, respectively. We determined myocardial and circulating miRNA abundance and its changes in patients with stable and end-stage HF before and at different time points after mechanical unloading by a left ventricular assist device (LVAD) by small RNA sequencing. miRNA changes in failing heart ti  ...[more]

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