Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Affymetrix gene expression of Transitional Type-1 B-cells from Wild-type (CBA), Xid and Btk KO mice

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA234016 | ENA |

REPOSITORIES: ENA

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Publications

Distinct gene expression signature in Btk-defective T1 B-cells.

Lindvall Jessica M JM   Blomberg K Emelie M KE   Berglöf Anna A   Smith C I Edvard CI  

Biochemical and biophysical research communications 20060602 2


Bruton's tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase important for B-lymphocyte maturation. Mutations in Btk give rise to the primary immunodeficiency disease X-linked agammaglobulinemia (XLA) in man and X-linked immunodeficiency (Xid) in mice. Recent studies have subdivided the mouse immature, or transitional, B-cells into two distinct subsets according to their respective surface markers. Transitional type 1 (T1) and transitional type 2 (T2) cells are also located in distinct anatom  ...[more]

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