Dataset Information


Danio rerio

ABSTRACT: Gene expression profile after Spring Viraemia Carpae Virus (SVCV) infection in zebrafish mutants rag1 -/- versus wt

ORGANISM(S): Danio rerio  



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Zebra Fish Lacking Adaptive Immunity Acquire an Antiviral Alert State Characterized by Upregulated Gene Expression of Apoptosis, Multigene Families, and Interferon-Related Genes.

García-Valtanen Pablo P   Martínez-López Alicia A   López-Muñoz Azucena A   Bello-Perez Melissa M   Medina-Gali Regla M RM   Ortega-Villaizán María Del Mar MD   Varela Monica M   Figueras Antonio A   Mulero Víctoriano V   Novoa Beatriz B   Estepa Amparo A   Coll Julio J  

Frontiers in immunology 20170213

To investigate fish innate immunity, we have conducted organ and cell immune-related transcriptomic as well as immunohistologic analysis in mutant zebra fish (Danio rerio) lacking adaptive immunity (rag1-/-) at different developmental stages (egg, larvae, and adult), before and after infection with spring viremia carp virus (SVCV). The results revealed that, compared to immunocompetent zebra fish (rag1+/+ ), rag1-/- acquired increased resistance to SVCV with age, correlating with elevated transc  ...[more]

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