Genomics

Dataset Information

0

Mus musculus


ABSTRACT: CDH1 knockout in mice

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA236013 | ENA |

REPOSITORIES: ENA

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Publications


The cell adhesion molecule E-cadherin has critical functions in development and carcinogenesis. Impaired expression of E-cadherin has been associated with disrupted tissue homeostasis, progression of cancer and a worse patient prognosis. So far, the role of E-cadherin in homeostasis and carcinogenesis of the liver is not well understood. By use of a mouse model with liver-specific deletion of E-cadherin and administration of the carcinogen diethylnitrosamine, we demonstrate that loss of E-cadher  ...[more]

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