Genomics

Dataset Information

235

Mus musculus


ABSTRACT: Mus musculus Transcriptome or Gene expression

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA236015 | ENA |

REPOSITORIES: ENA

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Publications

The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy.

Chen Suet Nee SN   Gurha Priyatansh P   Lombardi Raffaella R   Ruggiero Alessandra A   Willerson James T JT   Marian A J AJ  

Circulation research 20131125 3


Mutations in the intercalated disc proteins, such as plakophilin 2 (PKP2), cause arrhythmogenic cardiomyopathy (AC). AC is characterized by the replacement of cardiac myocytes by fibro-adipocytes, cardiac dysfunction, arrhythmias, and sudden death.To delineate the molecular pathogenesis of AC.Localization and levels of selected intercalated disc proteins, including signaling molecules, were markedly reduced in human hearts with AC. Altered protein constituents of intercalated discs were associat  ...[more]

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