Dataset Information


Homo sapiens

ABSTRACT: lncRNAs and mRNAs expression profile in liver diseases including HCC

ORGANISM(S): Homo sapiens  



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Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1.

Yuan Sheng-xian SX   Wang Jie J   Yang Fu F   Tao Qi-fei QF   Zhang Jin J   Wang Li-li LL   Yang Yuan Y   Liu Hui H   Wang Zhen-guang ZG   Xu Qing-guo QG   Fan Jia J   Liu Lei L   Sun Shu-han SH   Zhou Wei-ping WP  

Hepatology (Baltimore, Md.) 20150722 2

Tumor cells with stemness (stem-cell) features contribute to initiation and progression of hepatocellular carcinoma (HCC), but involvement of long noncoding RNAs (lncRNAs) remains largely unclear. Genome-wide analyses were applied to identify tumor-associated lncRNA-DANCR. DANCR expression level and prognostic values of DANCR were assayed in two HCC cohorts (China and Korea, n = 135 and 223). Artificial modulation of DANCR (down- and overexpression) was done to explore the role of DANCR in tumor  ...[more]

Publication: 1/2

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