Genomics

Dataset Information

235

Mycobacterium tuberculosis H37Rv


ABSTRACT: The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis [ChIP-Seq]

ORGANISM(S): Mycobacterium tuberculosis H37Rv  

PROVIDER: PRJNA236024 | ENA |

REPOSITORIES: ENA

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Publications

The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis.

Solans Luis L   Gonzalo-Asensio Jesús J   Sala Claudia C   Benjak Andrej A   Uplekar Swapna S   Rougemont Jacques J   Guilhot Christophe C   Malaga Wladimir W   Martín Carlos C   Cole Stewart T ST  

PLoS pathogens 20140529 5


The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specific cell wall components and attenuation both ex vivo and in vivo. Using antibodies against the native protein in ChIP-seq experiments (chromatin immunoprecipitation followed by high-throughput sequenc  ...[more]

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