Dataset Information


Mus musculus

ABSTRACT: Genome-wide analysis of gene expression changes in mouse tongue squamous cell carcinomas induced by 4-nitroquinoline 1-oxide (4-NQO)

ORGANISM(S): Mus musculus  



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Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.

Tang Xiao-Han XH   Osei-Sarfo Kwame K   Urvalek Alison M AM   Zhang Tuo T   Scognamiglio Theresa T   Gudas Lorraine J LJ  

Proceedings of the National Academy of Sciences of the United States of America 20140603 24

We investigated the effects of bexarotene (a retinoid X receptor agonist), CD1530 (a retinoic acid receptor γ selective agonist), and the combination of these two drugs for the prevention of oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide (4-NQO) in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma previously generated in our laboratory. We observed decreased numbers of neoplastic tongue lesions and reduced lesion severity in the 4-NQO plus CD1530 (  ...[more]

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