Genomics

Dataset Information

0


ABSTRACT: Drug-induced liver injury

PROVIDER: PRJNA236044 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.

Fredriksson Lisa L   Wink Steven S   Herpers Bram B   Benedetti Giulia G   Hadi Mackenzie M   de Bont Hans H   Groothuis Geny G   Luijten Mirjam M   Danen Erik E   de Graauw Marjo M   Meerman John J   van de Water Bob B  

Toxicological Sciences 20140420 1


Drug-induced liver injury (DILI) is an important clinical problem. Here, we used a genomics approach to in detail investigate the hypothesis that critical drug-induced toxicity pathways act in synergy with the pro-inflammatory cytokine tumor necrosis factor α (TNFα) to cause cell death of liver HepG2 cells. Transcriptomics of the cell injury stress response pathways initiated by two hepatoxicants, diclofenac and carbamazepine, revealed the endoplasmic reticulum (ER) stress/translational initiati  ...[more]

Similar Datasets

| PRJNA219214 | ENA
| PRJNA219213 | ENA
| phs000663 | dbGaP
2017-07-10 | PXD006313 | Pride
2012-09-08 | E-MEXP-3364 | ArrayExpress
| GSE59565 | GEO
2016-08-09 | E-GEOD-75277 | ArrayExpress
| PRJNA354381 | ENA
2013-12-01 | E-GEOD-44317 | ArrayExpress
2013-08-05 | E-MTAB-1747 | ArrayExpress