Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Microarray gene expression analysis: Batch effect removal improves the cross-platform consistency

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA236097 | ENA |

REPOSITORIES: ENA

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Publications

Microarray-based RNA profiling of breast cancer: batch effect removal improves cross-platform consistency.

Larsen Martin J MJ   Thomassen Mads M   Tan Qihua Q   Sørensen Kristina P KP   Kruse Torben A TA  

BioMed research international 20140703


Microarray is a powerful technique used extensively for gene expression analysis. Different technologies are available, but lack of standardization makes it challenging to compare and integrate data. Furthermore, batch-related biases within datasets are common but often not tackled. We have analyzed the same 234 breast cancers on two different microarray platforms. One dataset contained known batch-effects associated with the fabrication procedure used. The aim was to assess the significance of  ...[more]

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