Dataset Information


Mus musculus

ABSTRACT: Expression data from M0505 and STOSE murine ovarian surface epithelial cell lines



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A new spontaneously transformed syngeneic model of high-grade serous ovarian cancer with a tumor-initiating cell population.

McCloskey Curtis W CW   Goldberg Reuben L RL   Carter Lauren E LE   Gamwell Lisa F LF   Al-Hujaily Ensaf M EM   Collins Olga O   Macdonald Elizabeth A EA   Garson Kenneth K   Daneshmand Manijeh M   Carmona Euridice E   Vanderhyden Barbara C BC  

Frontiers in oncology 20140318

Improving screening and treatment options for patients with epithelial ovarian cancer has been a major challenge in cancer research. Development of novel diagnostic and therapeutic approaches, particularly for the most common subtype, high-grade serous ovarian cancer (HGSC), has been hampered by controversies over the origin of the disease and a lack of spontaneous HGSC models to resolve this controversy. Over long-term culture in our laboratory, an ovarian surface epithelial (OSE) cell line spo  ...[more]

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