Dataset Information


Mus musculus

ABSTRACT: Expression data from quiescent and activated neural stem cells from the adult mouse V-SVZ niche

ORGANISM(S): Mus musculus  



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Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche.

Codega Paolo P   Silva-Vargas Violeta V   Paul Alex A   Maldonado-Soto Angel R AR   Deleo Annina M AM   Pastrana Erika E   Doetsch Fiona F  

Neuron 20140501 3

Adult neurogenic niches harbor quiescent neural stem cells; however, their in vivo identity has been elusive. Here, we prospectively isolate GFAP(+)CD133(+) (quiescent neural stem cells [qNSCs]) and GFAP(+)CD133(+)EGFR(+) (activated neural stem cells [aNSCs]) from the adult ventricular-subventricular zone. aNSCs are rapidly cycling, highly neurogenic in vivo, and enriched in colony-forming cells in vitro. In contrast, qNSCs are largely dormant in vivo, generate olfactory bulb interneurons with s  ...[more]

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