Dataset Information


Mus musculus

ABSTRACT: miR-302-367 regulates cardiomycyte proliferation and differentiation during development

ORGANISM(S): Mus musculus  



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A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice.

Tian Ying Y   Liu Ying Y   Wang Tao T   Zhou Ning N   Kong Jun J   Chen Li L   Snitow Melinda M   Morley Michael M   Li Deqiang D   Petrenko Nataliya N   Zhou Su S   Lu Minmin M   Gao Erhe E   Koch Walter J WJ   Stewart Kathleen M KM   Morrisey Edward E EE  

Science translational medicine 20150301 279

In contrast to lower vertebrates, the mammalian heart has limited capacity to regenerate after injury in part due to ineffective reactivation of cardiomyocyte proliferation. We show that the microRNA cluster miR302-367 is important for cardiomyocyte proliferation during development and is sufficient to induce cardiomyocyte proliferation in the adult and promote cardiac regeneration. In mice, loss of miR302-367 led to decreased cardiomyocyte proliferation during development. In contrast, increase  ...[more]

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