Dataset Information


Mus musculus

ABSTRACT: MicroRNA-15/16 Antagonizes c-Myb to Control Natural Killer Cell Maturation

ORGANISM(S): Mus musculus  



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MicroRNA-15/16 Antagonizes Myb To Control NK Cell Maturation.

Sullivan Ryan P RP   Leong Jeffrey W JW   Schneider Stephanie E SE   Ireland Aaron R AR   Berrien-Elliott Melissa M MM   Singh Anvita A   Schappe Timothy T   Jewell Brea A BA   Sexl Veronika V   Fehniger Todd A TA  

Journal of immunology (Baltimore, Md. : 1950) 20150812 6

NK cells develop in the bone marrow and complete their maturation in peripheral organs, but the molecular events controlling maturation are incompletely understood. The miR-15/16 family of microRNA regulates key cellular processes and is abundantly expressed in NK cells. In this study, we identify a critical role for miR-15/16 in the normal maturation of NK cells using a mouse model of NK-specific deletion, in which immature NK cells accumulate in the absence of miR-15/16. The transcription fact  ...[more]

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