Dataset Information


Homo sapiens

ABSTRACT: MicroRNA expression profile in TRAIL-sensitive and -resistant H460 cells



altmetric image


A set of NF-κB-regulated microRNAs induces acquired TRAIL resistance in lung cancer.

Jeon Young-Jun YJ   Middleton Justin J   Kim Taewan T   Laganà Alessandro A   Piovan Claudia C   Secchiero Paola P   Nuovo Gerard J GJ   Cui Ri R   Joshi Pooja P   Romano Giulia G   Di Leva Gianpiero G   Lee Bum-Kyu BK   Sun Hui-Lung HL   Kim Yonghwan Y   Fadda Paolo P   Alder Hansjuerg H   Garofalo Michela M   Croce Carlo M CM  

Proceedings of the National Academy of Sciences of the United States of America 20150615 26

TRAIL (TNF-related apoptosis-inducing ligand) is a promising anticancer agent that can be potentially used as an alternative or complementary therapy because of its specific antitumor activity. However, TRAIL can also stimulate the proliferation of cancer cells through the activation of NF-κB, but the exact mechanism is still poorly understood. In this study, we show that chronic exposure to subtoxic concentrations of TRAIL results in acquired resistance. This resistance is associated with the i  ...[more]

Similar Datasets

| E-GEOD-55821 | BioStudies
| E-GEOD-55859 | BioStudies
2014-09-01 | E-GEOD-55821 | ArrayExpress
| PRJNA241163 | ENA
2014-09-01 | E-GEOD-55859 | ArrayExpress
| PRJNA299134 | ENA
2014-09-08 | E-GEOD-55859 | ExpressionAtlas
2014-01-01 | S-EPMC4148114 | BioStudies
| S-EPMC6013189 | BioStudies
| S-EPMC6984779 | BioStudies