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Homo sapiens

ABSTRACT: The age and genomic integrity of neurons after cortical stroke in humans

OTHER RELATED OMICS DATASETS IN: E-GEOD-56267

PROVIDER: PRJNA242801 | ENA |

REPOSITORIES: ENA

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The age and genomic integrity of neurons after cortical stroke in humans

Project description:It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA-rearrangements in the human neocortex. We show here that neither is the case, using immunohistochemistry, transcriptome-, genome- and ploidy-analyses, and determination of nuclear bomb test-derived 14C-concentration in neuronal DNA. A large proportion of cortical neurons display DNA-fragmentation and DNA-repair short time after stroke, whereas neurons at chronic stages after stroke show DNA-integrity, demonstrating the relevance of an intact genome for survival. Analyze of potential fusion transcripts in 13 samples, seven cortical ischemic stroke tissue and six control cortex, by deep sequencing using Illumina HiSeq 2000

2014-03-28 | E-GEOD-56267 | biostudies-arrayexpress

The age and genomic integrity of neurons after cortical stroke in humans

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