Dataset Information


Homo sapiens

ABSTRACT: InFusion: advancing discovery of fusion genes and chimeric transcripts from RNA-seq data

ORGANISM(S): Homo sapiens  



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InFusion: Advancing Discovery of Fusion Genes and Chimeric Transcripts from Deep RNA-Sequencing Data.

Okonechnikov Konstantin K   Imai-Matsushima Aki A   Paul Lukas L   Seitz Alexander A   Meyer Thomas F TF   Garcia-Alcalde Fernando F  

PloS one 20161201 12

Analysis of fusion transcripts has become increasingly important due to their link with cancer development. Since high-throughput sequencing approaches survey fusion events exhaustively, several computational methods for the detection of gene fusions from RNA-seq data have been developed. This kind of analysis, however, is complicated by native trans-splicing events, the splicing-induced complexity of the transcriptome and biases and artefacts introduced in experiments and data analysis. There a  ...[more]

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