Project description:This SuperSeries is composed of the following subset Series: GSE34158: Expression data from peripheral blood - blood draws at Pre and Post time points of Allergen inhalation challenge (PAX.GR) GSE34159: Expression data from peripheral blood - blood draws at Pre and Post time points of Allergen inhalation challenge (PAX.NGR) GSE34160: Expression data from peripheral blood - blood draws at Pre and Post time points of Allergen inhalation challenge (PAX.NGR and EDTA) Refer to individual Series
Project description:Acute metabolic challenges provide insight on how the body responds to metabolic stress. In this study, we assessed transcriptomic response in peripheral blood mononuclear cells (PBMC) to an acute lipid challenge.
Project description:Evaluate the effect of methacholine-induced bronchoconstriction on the peripheral whole-blood transcriptome, post-challenge compared to pre-challenge. Blood was collected immediately prior to, and two hours after challenge.
Project description:Detecting differential changes in the peripheral whole-blood transcriptome, post-challenge compared to pre-challenge; using globin reduced PAXgene (PAX.GR) tubes
Project description:Detecting differential changes in the peripheral whole-blood transcriptome, post-challenge compared to pre-challenge; using non-globin reduced PAXgene (PAX.NGR) tubes Blood was collected immediately prior to, and two hours after challenge
Project description:Evaluate the effect of methacholine-induced bronchoconstriction on the peripheral whole-blood transcriptome, post-challenge compared to pre-challenge. Blood was collected immediately prior to, and two hours after challenge. 28 total blood samples (14 Pre- and 14 Post-challenge) were analyzed. Robust regression in the Linear Models for MicroArrays (LIMMA) was used to compaire gene expression between Pre and Post time points. No pre-filtering of probe sets was performed prior to statistical analyses. In addtion, and FDR of 10% was used to deteremine signifance of genes.
