Dataset Information


Homo sapiens

ABSTRACT: Transcriptome analysis of LSD2-depleted HepG2 cells

ORGANISM(S): Homo sapiens  



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Lysine-specific demethylase 2 suppresses lipid influx and metabolism in hepatic cells.

Nagaoka Katsuya K   Hino Shinjiro S   Sakamoto Akihisa A   Anan Kotaro K   Takase Ryuta R   Umehara Takashi T   Yokoyama Shigeyuki S   Sasaki Yutaka Y   Nakao Mitsuyoshi M  

Molecular and cellular biology 20150126 7

Cells link environmental fluctuations, such as nutrition, to metabolic remodeling. Epigenetic factors are thought to be involved in such cellular processes, but the molecular basis remains unclear. Here we report that the lysine-specific demethylase 2 (LSD2) suppresses the flux and metabolism of lipids to maintain the energy balance in hepatic cells. Using transcriptome and chromatin immunoprecipitation-sequencing analyses, we revealed that LSD2 represses the genes involved in lipid influx and m  ...[more]

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