Genomics

Dataset Information

0

Mus musculus


ABSTRACT: LncRNAs expression profiling in adipose tissues and during brown adipocyte differentiation

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA247393 | ENA |

REPOSITORIES: ENA

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Publications

A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation.

Zhao Xu-Yun XY   Li Siming S   Wang Guo-Xiao GX   Yu Qi Q   Lin Jiandie D JD  

Molecular cell 20140704 3


Brown and beige/brite fats generate heat via uncoupled respiration to defend against cold. The total mass and activity of thermogenic adipose tissues are also tightly linked to systemic energy and nutrient homeostasis. Despite originating from distinct progenitors, brown and beige adipocytes acquire remarkably similar molecular and metabolic characteristics during differentiation through the action of a network of transcription factors and cofactors. How this regulatory network interfaces with l  ...[more]

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