Genomics

Dataset Information

0

Mus musculus


ABSTRACT: The homeoprotein Six2 promotes breast cancer metastasis via transcriptional and epigenetic control of E-cadherin expression

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA247776 | ENA |

REPOSITORIES: ENA

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Publications

Homeoprotein Six2 promotes breast cancer metastasis via transcriptional and epigenetic control of E-cadherin expression.

Wang Chu-An CA   Drasin David D   Pham Catherine C   Jedlicka Paul P   Zaberezhnyy Vadym V   Guney Michelle M   Li Howard H   Nemenoff Raphael R   Costello James C JC   Tan Aik-Choon AC   Ford Heide L HL  

Cancer research 20141027 24


Misexpression of developmental transcription factors occurs often in human cancers, where embryonic programs may be reinstated in a context that promotes or sustains malignant development. In this study, we report the involvement of the kidney development transcription factor Six2 in the metastatic progression of human breast cancer. We found that Six2 promoted breast cancer metastasis by a novel mechanism involving both transcriptional and epigenetic regulation of E-cadherin. Downregulation of  ...[more]

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