Dataset Information


Mus musculus

ABSTRACT: Inhibition of p38 MAPK in DC progenitor cells endows DCs with superior immunogenicity

ORGANISM(S): Mus musculus  



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p38 MAPK-inhibited dendritic cells induce superior antitumour immune responses and overcome regulatory T-cell-mediated immunosuppression.

Lu Yong Y   Zhang Mingjun M   Wang Siqing S   Hong Bangxing B   Wang Zhiqiang Z   Li Haiyan H   Zheng Yuhuan Y   Yang Jing J   Davis Richard E RE   Qian Jianfei J   Hou Jian J   Yi Qing Q  

Nature communications 20140624

Dendritic cell (DC)-based cancer immunotherapy is a promising method, but so far has demonstrated limited clinical benefits. Regulatory T cells (Tregs) represent a major obstacle to cancer immunotherapy approaches. Here we show that inhibiting p38 MAPK during DC differentiation enables DCs to activate tumour-specific effector T cells (Teff), inhibiting the conversion of Treg and compromising Treg inhibitory effects on Teff. Inhibition of p38 MAPK in DCs lowers expression of PPARγ, activating p50  ...[more]

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