Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Genomic and functional characterization of human T cell responses to co-stimulation with an agonistic anti-CD27 mAb, 1F5 (Varlilumab)

PROVIDER: PRJNA251856 | ENA |

REPOSITORIES: ENA

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Publications

Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab.

Ramakrishna Venky V   Sundarapandiyan Karuna K   Zhao Biwei B   Bylesjo Max M   Marsh Henry C HC   Keler Tibor T  

Journal for immunotherapy of cancer 20150818


<h4>Background</h4>Clinical targeting of TNFR family of receptors (CD40, CD134 and CD137) with immunostimulatory monoclonal antibodies has been successful in cancer immunotherapy. However, targeting of CD27 with a mAb is a relatively new approach to provide costimulation of immune cells undergoing activation. Thus, activation of human CD27 (TNFRSF7) with a monoclonal antibody (varlilumab) has previously been demonstrated to result in T cell activation and anti-tumor activity in preclinical model  ...[more]

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