Dataset Information


Mus musculus

ABSTRACT: Expression data from mouse luminal mammary epithelial cells

ORGANISM(S): Mus musculus  



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Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium.

Kunasegaran Kamini K   Ho Victor V   Chang Ted H-T TH   De Silva Duvini D   Bakker Martijn L ML   Christoffels Vincent M VM   Pietersen Alexandra M AM  

PloS one 20141024 10

The transcriptional repressor Tbx3 is involved in lineage specification in several tissues during embryonic development. Germ-line mutations in the Tbx3 gene give rise to Ulnar-Mammary Syndrome (comprising reduced breast development) and Tbx3 is required for mammary epithelial cell identity in the embryo. Notably Tbx3 has been implicated in breast cancer, which develops in adult mammary epithelium, but the role of Tbx3 in distinct cell types of the adult mammary gland has not yet been characteri  ...[more]

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