Genomics

Dataset Information

118

Spatiotemporal regulation of GLI target genes in the mammalian limb bud


ABSTRACT: Spatiotemporal regulation of GLI target genes in the mammalian limb bud

PROVIDER: PRJNA253126 | ENA |

REPOSITORIES: ENA

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Spatiotemporal regulation of GLI target genes in the mammalian limb bud.

Lewandowski Jordan P JP   Du Fang F   Zhang Shilu S   Powell Marian B MB   Falkenstein Kristin N KN   Ji Hongkai H   Vokes Steven A SA  

Developmental biology 20150731 1


GLI proteins convert Sonic hedgehog (Shh) signaling into a transcriptional output in a tissue-specific fashion. The Shh pathway has been extensively studied in the limb bud, where it helps regulate growth through a SHH-FGF feedback loop. However, the transcriptional response is still poorly understood. We addressed this by determining the gene expression patterns of approximately 200 candidate GLI-target genes and identified three discrete SHH-responsive expression domains. GLI-target genes expr  ...[more]

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