Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Chemical conversion of human fibroblasts into functional Schwann cells

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA254474 | ENA |

REPOSITORIES: ENA

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Publications


Direct transdifferentiation of somatic cells is a promising approach to obtain patient-specific cells for numerous applications. However, conversion across germ-layer borders often requires ectopic gene expression with unpredictable side effects. Here, we present a gene-free approach that allows efficient conversion of human fibroblasts via a transient progenitor stage into Schwann cells, the major glial cell type of peripheral nerves. Using a multikinase inhibitor, we transdifferentiated fibrob  ...[more]

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